Title Postdoctoral Research position available immediately The Lindsley F. Kimball Research Institute of the New York Blood Center Laboratory of Molecular Parasitology
Salary competitive salary and a comprehensive benefit package
Location New York Blood Center, New York, U.S.A.
Job Information

We are seeking candidates for a postdoctoral position (junior or senior, or a staff scientist position) in immunology and vaccinology. The postdoctoral research fellow will be involved in projects that center on the identification and utilization of naturally secreted proteins of the filarial parasite Onchocerca volvulus and Brugia malayi as biologics (immunomodulatory and/or immunostimulatory proteins) for human use.

One aspect of the research is to continue studying the mechanism of action of the O. volvulus protein Ov-ASP-1, which has intrinsic immunostimulatory properties and can be used as a powerful immunostimulatory adjuvant. Ov-ASP-1 promotes a balanced Th1/Th2 antibody response and cellular responses to several soluble bystander vaccine antigens and commercial inactivated viral vaccines, including the trivalent-inactivated flu vaccines. One objective is to develop this highly effective and safe protein adjuvant on its own or in combination with other innate adjuvants for varied prophylactic vaccines using a simple formulation, antigen sparing and as an effective vaccine also in the elderly. The research projects have therefore translational implications for the prevention of various infectious diseases. Another objective is to also study the mechanism of action of this adjuvant in synergy with other adjuvants.

Another translational project involves the identification and in-depth characterization of putative filarial parasite-derived immunomodulators that can suppress pro-inflammatory and autoimmune diseases in vitro and in vivo using various mouse models.

Applicants should have a PhD and/or MD with at least 3-5 years of experience and knowledge in innate and adaptive immunity (human and mouse), system biology, vaccinology, and the study of mechanism of action of adjuvants, vaccines, and immunomodulatory molecules, with interest in the translational aspects of these disciplines. Some experience in molecular techniques, bioinformatics and the use of experimental animal models is also required. Excellent analytical and communication skills and a drive to independently ask and test scientific hypotheses are crucial. The appointed person is expected to be productive, creative, self-motivated with a good track record in the broader discipline of immunology with practical knowledge in cellular and molecular immunological techniques, be able to work efficiently, carefully organize experiments, and work as a member of a team.

We offer a competitive salary and a comprehensive benefit package. The New York Blood Center is an Equal Opportunity Employer. The title of the position will be decided based on the qualification of the appointed person. The Lindsley F. Kimball Research Institute is a multi-disciplinary biomedical research institute with about 70 scientists in 20 independent laboratories (Lindsley F. Kimball Research Institute | New York Blood Center (nybloodcenter.org). The Institute is located within 2 blocks of Rockefeller University, Weill Cornell Medical College, and the Memorial Sloan Kettering Institute.

Interested applicants should send Curriculum vitae, statement of interest and the names, addresses and Telephone/E-mails of three references to:

Sara Lustigman, Ph.D.,

Head, Laboratory of Molecular Parasitology

Member, Lindsley F. Kimball Research Institute, New York Blood Center

310 East 67th St., New York, NY 10065, USA

Phone : 212-570-3119

E-mail: slustigman@nybc.org

Link: Sara Lustigman, PhD | New York Blood Center (nybloodcenter.org)

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